Alizarin complexone

Alizarin complexone is a calcium-binding fluorescent dye. Alizarin complexone stains mineralized areas of bone by binding to calcium crystals. Alizarin complexone inhibits the reverse transcriptase activity of RAV-2, HIV-1, and RSV with IC50 values of 3.8 μg/mL, 45 μg/mL, and 100 μg/mL, respectively. Alizarin complexone exhibits antiviral activity against HIV-1 and RSV. Alizarin complexone delays RSV-induced tumor induction in chickens[1][2][3][4].

Product Specifications

CAS Number

[3952-78-1]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Fluorescent Dye; HIV; Reverse Transcriptase; RSV

Type

Reference compound

Related Pathways

Anti-infection; Others

Applications

COVID-19-anti-virus

Field of Research

Cancer; Infection; Endocrinology

Assay Protocol

https://www.medchemexpress.com/alizarin-complexone.html

Purity

98.0

Solubility

DMSO : ≥ 100 mg/mL

Smiles

O=C(C1=C(C(O)=C(C=C1C2=O)CN(CC(O)=O)CC(O)=O)O)C3=C2C=CC=C3

Molecular Formula

C19H15NO8

Molecular Weight

385.32

Precautions

H302, H315, H319, H335

References & Citations

[1]Higuchi H, et al. Antiretroviral activities of anthraquinones and their inhibitory effects on reverse transcriptase. Antiviral Res. 1991;15 (3) :205-216. |[2]Oshima T, et al. Selective extraction of histidine derivatives by metal affinity with a copper (II) -chelating ligand complex in an aqueous two-phase system. J Chromatogr B Analyt Technol Biomed Life Sci. 2015;990:73-79.|[3]Yu T, et al. Live imaging of osteoclast inhibition by bisphosphonates in a medaka osteoporosis model. Dis Model Mech. 2016 Feb;9 (2) :155-63. |[4]Cui M, et al. New role of calcium-binding fluorescent dye alizarin complexone in detecting permeability from articular cartilage to subchondral bone. FASEB Bioadv. 2024 Oct 7;6 (11) :539-554.