Antitumor agent-180
Product Specifications
UNSPSC Description
Antitumor agent-180 (Compound 13a) is an inhibitor for BUB1 mitotic checkpoint serine/threonine kinase B (BUB1B). Antitumor agent-180 inhibits the proliferation of ccRCC cell Caki-1 with IC50 of 2.047 µM. Antitumor agent-180 induces necrosis and apoptosis in Caki-1[1].
Target Antigen
Apoptosis
Type
Reference compound
Related Pathways
Apoptosis
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/antitumor-agent-180.html
Smiles
CN(CC1)CCN1C2=CC=C(NC3=C(C)C=NC(NC4=CC=C(C(NC5=CC=C(N6CCN(C)CC6)C=C5)=O)C=C4)=N3)C=C2
Molecular Weight
591.75
References & Citations
[1]Bouzian Y, et al., Design and evaluation of novel inhibitors for the treatment of clear cell renal cell carcinoma. Bioorg Chem. 2024 Jul 6;151:107597.
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-161865/Antitumor-agent-180-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-161865/
Clinical Information
No Development Reported
CAS Number
9007-83-4
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