Anti-MHC II (HLA-DP) (beta chain)(BRA-FB6)
Recognizes a non-polymorphic determinant of DP-MHC class II. MHC class II antigens are transmembrane glycoproteins of non-covalently linkedalpha (33-35 kDa) and beta (27-30 kDa) chains. It reportedly reacts with B- & non-T, non-B cell lines but not with T- and myeloid cell lines and leukemias. Differential expression of MHC class II antigens on fetal and adult lymphocytes, malignant B cells appears to reflect the stage of cell differentiation which may be useful in the study of lymphoproliferative disorders._x000D__x000D_Primary antibodies are available purified, or with a selection of fluorescent CF® Dyes and other labels. CF® Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.
Product Specifications
Synonyms
Ia3; Ia-3; H-2Ea; H2-Ea; AI323765; I-Ealpha; E-alpha-f; MHC-H2-Ea
UNSPSC
41116161
UNSPSC Description
Primary and secondary antibodies for multiple methodology immunostaining detection application
Gene Name
HLA-DPB1
Gene ID
3115
NCBI Gene ID
347270
UniProt
P04440
Cellular Locus
Plasma membrane
Host
Mouse
Species Reactivity
Human
Immunogen
Non-T, non-B human acute lymphoblastic leukemia REH6 cell line
Target Antigen
MHC-II
Clonality
Monoclonal
Isotype
IgG2b κ
Clone
BRA-FB6
Conjugation
Purified, with BSA
Source
Animal
Applications
Flow (verified) | Flow, surface (published) | Functional studies (published) | ELISA (published) | IP (published)
Validated Applications
FC,FC,ELISA,IP
Field of Research
Immunology, MHC antigens
Positive Control
Raji cells. Tonsil or lymph node
Concentration
0.2 mg/mL
Buffer
PBS, 0.05% BSA, 0.05% azide
Molecular Weight
33-35 kDa
Additionnal Information
References & Citations
Shipping Conditions
Room temperature
Storage Conditions
4°C; Stable at room temperature or 37°C (98°F) for 7 days.
Shelf Life
2 years
Product Datasheet
https://cdn.gentaur.com/products/37/885667/datasheet/bnub0199-500.pdf
Product MSDS
https://cdn.gentaur.com/products/37/885667/msds/bnub0199-500.pdf
CAS Number
9007-83-4
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