Welcome to GenPrice! Check out our latest updates.

Shopping Cart (0)

Your cart is empty

Add some products to get started!

Anti-Ku-Holo (p70;83)(KU729)

Recognizes a dimer of two proteins of 70 kDa and ~80 kDa, identified as two subunits of Ku. This MAb recognizes a conformational epitope of p70/p80 dimer, which is destroyed during Western blotting. The p70/p80 dimer is important for function of a 460 kDa DNA-dependent protein kinase. Ku protein plays a role in cell signaling, proliferation, DNA repair, replication, transcriptional activation, and apoptosis._x000D__x000D_Primary antibodies are available purified, or with a selection of fluorescent CF® Dyes and other labels. CF® Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors._x000D_

Product Specifications

Synonyms

Ku (p70): 70kDa subunit of Ku antigen; ATP dependent DNA helicase 2 subunit 1; ATP-dependent DNA helicase II 70kDa subunit; CTC box-binding factor 75kDa subunit; CTC75; CTCBF; DNA repair protein XRCC6; G22P1; Ku autoantigen, 70kDa; Ku70; Kup70; Lupus Ku autoantigen protein p70; ML8; Thyroid autoantigen 70kD (Ku antigen); Thyroid-lupus autoantigen (TLAA); X-ray repair cross-complementing protein 6 (XRCC6) Ku (p80): 86kDa subunit of Ku antigen; ATP dependent DNA helicase 2 subunit 2; ATP dependent DNA helicase II 86Kd subunit; ATP-dependent DNA helicase II 80kDa subunit; CTC box-binding factor 85kDa subunit; CTC85; CTCBF; DNA repair protein XRCC5; KARP1; Ku autoantigen 80kDa; Ku80; Ku86 autoantigen related protein 1; KUB2; Lupus Ku autoantigen protein p86; Nuclear factor IV (NFIV); Thyroid-lupus autoantigen (TLAA); X-ray repair cross-complementing protein 5 (XRCC5)

UNSPSC

41116161

UNSPSC Description

Primary and secondary antibodies for multiple methodology immunostaining detection application

Gene Name

XRCC6

Gene ID

2547 (p70); 7520 (p80)

NCBI Gene ID

292493 (p70); 388739 (p80)

UniProt

P12956 (p70); P13010 (p80)

Cellular Locus

Nucleus

Host

Mouse

Species Reactivity

Human,Non-human primates

Immunogen

Nuclear extract of human HL-60 cells

Target Antigen

Ku-Holo

Clonality

Monoclonal

Isotype

IgG1 κ

Clone

KU729

Conjugation

Purified, with BSA

Source

Animal

Applications

Flow, intracellular (verified) | IF (verified)

Validated Applications

FC,IF

Field of Research

Apoptosis, Cell cycle, Signal transduction

Positive Control

Human cancer K562, HL-60, HEp-2 or HeLa cells

Concentration

0.2 mg/mL

Buffer

PBS, 0.05% BSA, 0.05% azide

Molecular Weight

70 kDa & 80 kDa

Additionnal Information

Higher concentration may be required for direct detection using primary antibody conjugates than for indirect detection with secondary antibody|Immunofluorescence: 0.5-1 ug/mL|Immunocytochemistry acetone-fixed cells 0.25-0.5 ug/mL|Flow Cytometry 0.5-1 ug/million cells/0.1 mL|Does not react with mouse, rat or chicken; others not known|Optimal dilution for a specific application should be determined by user

Shipping Conditions

Room temperature

Storage Conditions

4°C; Stable at room temperature or 37°C (98°F) for 7 days.

Shelf Life

2 years

Product Datasheet

https://cdn.gentaur.com/products/37/884261/datasheet/bnub0729-500.pdf

Product MSDS

https://cdn.gentaur.com/products/37/884261/msds/bnub0729-500.pdf

CAS Number

9007-83-4

Curated Selection

Explore Other Products

Discover premium biology products from our extensive collection of 20M+ items

PAQR3 sgRNA CRISPR/Cas9 All-in-One Lentivector set (Human)
35999111 3 x 1.0 µg

PAQR3 sgRNA CRISPR/Cas9 All-in-One Lentivector set (Human)

Ask
View Details
NLK Antibody [APR17583G]
APR17583G-01 50 µL

NLK Antibody [APR17583G]

Ask
View Details
NLK Antibody [APR17583G]
APR17583G-02 100 µL

NLK Antibody [APR17583G]

Ask
View Details
NLK Antibody [APR17583G]
APR17583G-03 200 µL

NLK Antibody [APR17583G]

Ask
View Details
NLK Antibody [APR17583G]
APR17583G-04 400 µL

NLK Antibody [APR17583G]

Ask
View Details
CDC25A (NM_001789) Human Over-expression Lysate
LS000993 100 µg

CDC25A (NM_001789) Human Over-expression Lysate

Ask
View Details