TPNA10168

TPNA10168 is an Nrf-2 activator that activates the Keap1-Nrf2-ARE pathway. TPNA10168 is neuroprotective against oxidative stress-induced damage. TPNA10168 significantly reduces the transcription of inflammatory genes, including TNF-α, IL-1β, IL-6, and iNOS. TPNA10168 can be used in research on anti-inflammatory and neurological diseases[1].

Product Specifications

CAS Number

[957942-34-6]

Product Name Alternative

KM05073

UNSPSC

12352005

Hazard Statement

H302-H315-H319-H335

Target

Keap1-Nrf2

Type

Reference compound

Related Pathways

NF-κB

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/tpna10168.html

Solubility

10 mM in DMSO

Smiles

CS(=O)C1=C2C(=C(S1)Cl)CCCC2=O

Molecular Formula

C9H9ClO2S2

Molecular Weight

248.75

Precautions

P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

References & Citations

[1]Izumi Y, et al. TPNA10168, an Nrf-2 activator, attenuates inflammatory responses independently of Nrf2 in microglial BV-2 cells: Involvement of the extracellular-signal-regulated kinase pathway. J Pharmacol Sci. 2022 May;149 (1) :1-10.