Mephenesin

Mephenesin is an NMDA receptor antagonist. Mephenesin is also a central muscle relaxant with antianxiety, muscle-paralyzing and anticonvulsant effects. Mephenesin acts directly on the skeletal muscle fibres to produce skeletal muscle relaxation. Mephenesin is promising for research of spasticity or painful muscle spasm[1][2][3][4][5].

[1]Mephenesin: abuse and dependence. Prescrire Int. 2013 May;22(138):127-128.|[2]?cija P, et al. Conformational flexibility of mephenesin. J Phys Chem B. 2014 May 22;118(20):5357-5364.|[3]Crankshaw DP, et al. Mephenesin, methocarbamol, chlordiazepoxide and diazepam: actions on spinal reflexes and ventral root potentials. Br J Pharmacol. 1970 Jan;38(1):148-56.|[4]Ludwig B J, et al. Muscle-paralyzing compounds related to mephenesin[J]. Journal of the American Chemical Society, 1952, 74(8): 1935-1939.|[5]DIAZ-RIVERA RS, et al. Muscular relaxation in tetanus with special reference to the effect of mephenesin. Ann Intern Med. 1954 Mar;40(3):563-80.