Mephenesin

Mephenesin is an NMDA receptor antagonist. Mephenesin is also a central muscle relaxant with antianxiety, muscle-paralyzing and anticonvulsant effects. Mephenesin acts directly on the skeletal muscle fibres to produce skeletal muscle relaxation. Mephenesin is promising for research of spasticity or painful muscle spasm[1][2][3][4][5].

Product Specifications

CAS Number

[59-47-2]

UNSPSC

12352005

Hazard Statement

H302

Target

IGluR

Type

Reference compound

Related Pathways

Membrane Transporter/Ion Channel; Neuronal Signaling

Applications

Neuroscience-Neurodegeneration

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/Mephenesin.html

Purity

99.69

Solubility

DMSO : ≥ 100 mg/mL

Smiles

OCC(O)COC1=CC=CC=C1C

Molecular Formula

C10H14O3

Molecular Weight

182.22

Precautions

H302

References & Citations

[1]Mephenesin: abuse and dependence. Prescrire Int. 2013 May;22 (138) :127-128.|[2]?cija P, et al. Conformational flexibility of mephenesin. J Phys Chem B. 2014 May 22;118 (20) :5357-5364.|[3]Crankshaw DP, et al. Mephenesin, methocarbamol, chlordiazepoxide and diazepam: actions on spinal reflexes and ventral root potentials. Br J Pharmacol. 1970 Jan;38 (1) :148-56.|[4]Ludwig B J, et al. Muscle-paralyzing compounds related to mephenesin[J]. Journal of the American Chemical Society, 1952, 74 (8) : 1935-1939.|[5]DIAZ-RIVERA RS, et al. Muscular relaxation in tetanus with special reference to the effect of mephenesin. Ann Intern Med. 1954 Mar;40 (3) :563-80.