MS417

MS417 is a selective BET-specific BRD4 inhibitor, binds to BRD4-BD1 and BRD4-BD2 with IC50s of 30, 46 nM and Kds of 36.1, 25.4 nM, respectively, with weak selectivity at CBP BRD (IC50, 32.7 μM) .

Product Specifications

CAS Number

[916489-36-6]

Product Name Alternative

GTPL7512

UNSPSC

12352005

Target

Epigenetic Reader Domain; HIV

Type

Reference compound

Related Pathways

Anti-infection; Epigenetics

Applications

COVID-19-anti-virus

Field of Research

Infection; Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/MS417.html

Purity

99.79

Solubility

10 mM in DMSO|Ethanol : 50 mg/mL (ultrasonic)

Smiles

O=C(OC)C[C@H]1C2=NN=C(C)N2C3=C(C(C)=C(C)S3)C(C4=CC=C(Cl)C=C4)=N1

Molecular Formula

C20H19ClN4O2S

Molecular Weight

414.91

References & Citations

[1]Zhang G, et al. Down-regulation of NF-κB transcriptional activity in HIV-associated kidney disease by BRD4 inhibition. J Biol Chem. 2012 Aug 17;287 (34) :28840-51.