Nilotinib-d6
Nilotinib-d6 is a deuterium labeled Nilotinib. Nilotinib is an orally available Bcr-Abl tyrosine kinase inhibitor with antineoplastic activity[1].
Product Specifications
CAS Number
[1268356-17-7]
Product Name Alternative
AMN107-d6
UNSPSC
12352005
Hazard Statement
H372, H413
Target
Autophagy; Bcr-Abl
Type
Isotope-Labeled Compounds
Related Pathways
Autophagy; Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Purity
99.95
Solubility
DMSO : 125mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
O=C(NC1=CC(C(F)(F)F)=CC(N2C=C(C)N=C2)=C1)C3=C([2H])C(NC4=NC=CC(C5=CC=CN=C5)=N4)=C(C([2H])([2H])[2H])C([2H])=C3[2H]
Molecular Formula
C28H16D6F3N7O
Molecular Weight
535.55
Precautions
H372, H413
References & Citations
[1]Weisberg E, et al. Beneficial effects of combining nilotinib and imatinib in preclinical models of BCR-ABL+ leukemias. Blood. 2007 Mar 1;109 (5) :2112-20.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Isotope-Labeled Compounds
Clinical Information
No Development Reported
Available Sizes
Curated Selection
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