Pranoprofen

Pranoprofen is a non-steroidal anti-inflammatory agent (NSAID) for the research of keratitis or other ophthalmology diseases. Pranoprofen inhibit COX-1 and COX-2 enzymes, thus blocking arachidonic acid converted to eicosanoids and reducing prostaglandins synthesis[1][2].

Product Specifications

CAS Number

[52549-17-4]

UNSPSC

12352005

Hazard Statement

H301

Target

Apoptosis; COX; PGE synthase

Type

Reference compound

Related Pathways

Apoptosis; Immunology/Inflammation

Applications

Neuroscience-Neurodegeneration

Field of Research

Cancer; Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/Pranoprofen.html

Purity

98.65

Solubility

DMSO : ≥ 100 mg/mL

Smiles

CC(C(O)=O)C1=CC2=C(C=C1)OC3=NC=CC=C3C2

Molecular Formula

C15H13NO3

Molecular Weight

255.27

Precautions

H301

References & Citations

[1]Toru Hosoi, et al. Effect of pranoprofen on endoplasmic reticulum stress in the primary cultured glial cells. Neurochem Int. 2009 Jan;54 (1) :1-6.|[2]Minting Chen, et al. The Therapeutic Effects and Possible Mechanism of Pranoprofen in Mouse Model of Corneal Alkali Burns. J Ophthalmol. 2020 Apr 6;2020:7485912.|[3]Xiaoli Wu, et al. Rescuing Dicer expression in inflamed colon tissues alleviates colitis and prevents colitis-associated tumorigenesis. Theranostics. 2020 Apr 27;10 (13) :5749-5762.