SN40
SN40 is a potent amino acid transport (AAT) inhibitor with Kis of 7.29 μM, 2.42 μM, 2.94 μM, 5.55 μM, 24.43 μM and 5.55 μM for rat ASCT2, human ASCT2, EAAT1, EAAT2, EAAC1 and EAAT5, respectively. SN40 can be used for researching anticancer[1].
Product Specifications
CAS Number
[2768663-14-3]
UNSPSC
12352005
Target
ASCT; EAAT
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/sn40.html
Purity
99.26
Solubility
DMSO : 10 mg/mL (ultrasonic; adjust pH to 2 with 1M HCl)
Smiles
OC([C@@H](NC1)C[C@@H]1NCC2=CC=C(C3=CC=CC=C3)C=C2)=O
Molecular Formula
C18H20N2O2
Molecular Weight
296.36
References & Citations
[1]Grewer Christof, et al. Preparation of amino acids as inhibitors of alanine serine cysteine transporter 2. World Intellectual Property Organization, WO2022087630 A1 2022-04-28
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
ASCT2; EAAT1; EAAT2; EAAT3; EAAT5
Available Sizes
Curated Selection
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