CD6 (Negative Marker of T-regulatory Cells) (SPV-L14), CF405S conjugate, 0.1mg/mL
CD6 is a type I transmembrane glycoprotein that contains a 24-amino acid signal sequence, three extracellular scavenger receptor cysteine-rich (SRCR) domains, a membrane-spanning domain and a 44-amino acid cytoplasmic domain. The CD6 glycoprotein is tyrosine phosphorylated during TCR-mediated T cell activation. CD6 shows significant homology to CD5. CD6 is present on mature thymocytes, peripheral T cells and a subset of B cells. Antibodies to CD6 are used to deplete T cells from bone marrow transplants to prevent graft versus host disease.
Product Specifications
Synonyms
T12; TP120
UNSPSC
41116161
UNSPSC Description
Primary and secondary antibodies for multiple methodology immunostaining detection application
Gene Name
CD6
Gene ID
923
NCBI Gene ID
744366
UniProt
P30203
Swiss Prot
P30203
Host
Mouse
Species Reactivity
Human,Mouse
Reactivity
CD6
Immunogen
CD8 cytotoxic T-cell clone
Target Antigen
CD6
Clonality
Monoclonal
Clone
SPV-L14
Type
Primary
Source
Animal
Origin
Animal
Applications
Flow (verified) |Flow, surface (published) |Functional studies (published) |IF (published) |IF (verified)
Field of Research
Immunology
Positive Control
CCRF-CEM, Jurkat cells, Tonsil
Stability
2 years
Concentration
0.1 mg/mL
Buffer
PBS, 0.1% BSA, 0.05% azide
Molecular Weight
90-130 kDa
References & Citations
Shipping Conditions
RT (ND)
Storage Conditions
Stable at room temperature or 37°C (98°F) for 7 days.
Notes
Protect from light
Shelf Life
Guaranteed for at least 24 months from date of receipt when stored as recommended
Product Datasheet
https://cdn.gentaur.com/products/37/873170/datasheet/bnc040402-100.pdf
Product MSDS
https://biotium.com/wp-content/uploads/2018/06/SDS-primary-antibodies.pdf
Fragment
IgG1, kappa
Species
Mus musculus (mouse), BSA from bovine serum (Bos taurus) or recombinant BSA produced in Chinese hamster ovary cells.
Classification
0.05% sodium azide (CAS 26628-22-8)
CAS Number
9007-83-4
Conjugate
CF405S
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