PEG6- (CH2CO2H) 2

PEG6- (CH2CO2H) 2 is a symmetric PEG PROTAC linker, for the synthesis of Homo-PROTACs which is bivalent small-molecule dimerizers of the VHL E3 ubiquitin ligase to induce self-degradation[1].

Product Specifications

CAS Number

[77855-76-6]

UNSPSC

12352211

Hazard Statement

H302, H315, H319, H335

Target

PROTAC Linkers

Type

Reference compound

Related Pathways

PROTAC

Field of Research

Others

Assay Protocol

https://www.medchemexpress.com/peg6-ch2co2h-2.html

Purity

95.0

Solubility

Ethanol : 100 mg/mL (ultrasonic)

Smiles

O=C(O)COCCOCCOCCOCCOCCOCC(O)=O

Molecular Formula

C14H26O10

Molecular Weight

354.35

Precautions

H302, H315, H319, H335

References & Citations

[1]Maniaci C, et al. Homo-PROTACs: bivalent small-molecule dimerizers of the VHL E3 ubiquitin ligase to induce self-degradation. Nat Commun. 2017 Oct 10;8 (1) :830.