SIC-19
Product Specifications
UNSPSC Description
SIC-19 is a SIK2 inhibitor and promotes SIK2 protein degradation via the ubiquitination pathway. SIC-19 inhibits cancer cell growth and sensitizes cells to PARP inhibitors (Such as Olaparib (HY-10162)), as well as in ovarian cancer organoids and xenograft models[1].
Target Antigen
Salt-inducible Kinase (SIK)
Type
Reference compound
Related Pathways
Immunology/Inflammation
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/sic-19.html
Smiles
O=C(NC1=C(C(NNC(NC(C2=CC=CC=C2)=O)=S)=O)C(C3=CC=C(OC)C(OC)=C3)=C(C)S1)C4=CC=CC=C4
Molecular Weight
574.67
References & Citations
[1]Wang F, et al. A novel SIK2 inhibitor SIC-19 exhibits synthetic lethality with PARP inhibitors in ovarian cancer. Drug Resist Updat. 2024 May;74:101077.
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-163743/SIC-19-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-163743/
Clinical Information
No Development Reported
CAS Number
713112-69-7
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