Welcome to GenPrice! Check out our latest updates.

Shopping Cart (0)

Your cart is empty

Add some products to get started!

Corynoxine B (Standard)

Corynoxine B Standard is an analytical standard for Corynoxine B. This product is intended for research and analytical applications. Corynoxine B is an alkaloid-type autophagy inducer and α-synuclein aggregation inhibitor that ameliorates Mn-induced dysregulation of autophagy and enhances the clearance of α-synuclein (α-syn) in Parkinson's disease mice[1][2][3][4].

Product Specifications

UNSPSC

12352005

Target

Reference Standards; α-synuclein

Type

Reference Standards

Related Pathways

Neuronal Signaling; Others

Field of Research

Cancer; Neurological Disease

Assay Protocol

https://www.medchemexpress.com/corynoxine-b-standard.html

Smiles

O=C(NC1=C2C=CC=C1)[C@]32[C@@](C[C@H](/C(C(OC)=O)=C\OC)[C@H](CC)C4)([H])N4CC3

Molecular Formula

C22H28N2O4

Molecular Weight

384.47

References & Citations

[1]Yan D, et al. Corynoxine B ameliorates HMGB1-dependent autophagy dysfunction during manganese exposure in SH-SY5Y human neuroblastoma cells. Food Chem Toxicol. 2019 Feb;124:336-348.|[2]Song JX, et al. HMGB1 is involved in autophagy inhibition caused by SNCA/α-synuclein overexpression: a process modulated by the natural autophagy inducer corynoxine B. Autophagy. 2014 Jan;10 (1) :144-54. doi: 10.4161/auto.26751. Epub 2013 Jan 1. Erratum in: Autophagy. 2015;11 (9) :1708.|[3]Zhu Q, et al. Corynoxine B targets at HMGB1/2 to enhance autophagy for α-synuclein clearance in fly and rodent models of Parkinson's disease. Acta Pharm Sin B. 2023 Jun;13 (6) :2701-2714.|[4]Chen L, et al. Corynoxine Protects Dopaminergic Neurons Through Inducing Autophagy and Diminishing Neuroinflammation in Rotenone-Induced Animal Models of Parkinson's Disease. Front Pharmacol. 2021 Apr 13;12:642900.

Shipping Conditions

Room temperature

Product Datasheet

http://file.medchemexpress.com/batch_PDF/HY-N0901AR/Corynoxine-B-Standard-DataSheet-MedChemExpress.pdf

Product MSDS

http://file.medchemexpress.com/batch_PDF/HY-N0901AR/

Scientific Category

Reference Standards

Isoform

α-synuclein Aggregation

CAS Number

[17391-18-3]

Curated Selection

Explore Other Products

Discover premium biology products from our extensive collection of 20M+ items

KCNV2 Human Gene Knockout Kit (CRISPR)
KN416308 1 Kit

KCNV2 Human Gene Knockout Kit (CRISPR)

Ask
View Details
OR2A15P sgRNA CRISPR/Cas9 All-in-One Lentivector set (Human)
35026111 3 x 1.0 µg

OR2A15P sgRNA CRISPR/Cas9 All-in-One Lentivector set (Human)

Ask
View Details
Naphthoresorcinol AR (1,3-Dihydroxynaphthalene) 98.0%
308375-01 1 g

Naphthoresorcinol AR (1,3-Dihydroxynaphthalene) 98.0%

Ask
View Details
Naphthoresorcinol AR (1,3-Dihydroxynaphthalene) 98.0%
308375-02 5 g

Naphthoresorcinol AR (1,3-Dihydroxynaphthalene) 98.0%

Ask
View Details
26S Protease regulatory subunit 4 (PSMC1) Human ELISA Kit
B0354 96 Tests

26S Protease regulatory subunit 4 (PSMC1) Human ELISA Kit

Ask
View Details
Sonepcizumab (Reference antibody)
E55B0934 100 µg

Sonepcizumab (Reference antibody)

Ask
View Details