CGAS (161-522) Human Recombinant

<strong>cGAS (161-522) Human Recombinant</strong>_x000D_ <strong>Catalog number:</strong> B2017396_x000D_ <strong>Lot number:</strong> Batch Dependent_x000D_ <strong>Expiration Date:</strong> Batch dependent_x000D_ <strong>Amount:</strong> 100 µg_x000D_ <strong>Molecular Weight or Concentration:</strong> 44.6 kDa_x000D_ <strong>Supplied as:</strong> Solution_x000D_ <strong>Applications:</strong> a molecular tool for various biochemical applications_x000D_ <strong>Storage:</strong> -80°C_x000D_ <strong>Keywords:</strong> C6orf150, 2’3’-cGAMP Synthase, cGAMP Synthase, h-cGAS, Cyclic GMP-AMP Synthase, Mab-21 domain-containing protein 1, MB21D1_x000D_ <strong>Grade:</strong> Biotechnology grade. All products are highly pure. All solutions are made with Type I ultrapure water (resistivity &gt;18 MΩ-cm) and are filtered through 0.22 um._x000D_ _x000D_ <strong>References:</strong>_x000D_ 1: Zhang J, Zhang L, Chen Y, Fang X, Li B, Mo C. The role of cGAS-STING signaling in pulmonary fibrosis and its therapeutic potential Front Immunol. 2023 Oct 25;14:1273248._x000D_ 2: Wang C, Zhang R, He J, Yu L, Li X, Zhang J, Li S, Zhang C, Kagan JC, Karp JM, Kuai R. Ultrasound-responsive low-dose doxorubicin liposomes trigger mitochondrial DNA release and activate cGAS-STING-mediated antitumour immunity Nat Commun. 2023 Jun 30;14(1):3877._x000D_ 3: Huang Y, Lu C, Wang H, Gu L, Fu YX, Li GM. DNAJA2 deficiency activates cGAS-STING pathway via the induction of aberrant mitosis and chromosome instability Nat Commun. 2023 Aug 28;14(1):5246._x000D_ 4: Luo S, Luo R, Lu H, Zhang R, Deng G, Luo H, Yu X, Wang C, Zhang H, Zhang Y, Huang W, Sun J, Liu Y, Huang F, Lei Z. Activation of cGAS-STING signaling pathway promotes liver fibrosis and hepatic sinusoidal microthrombosis Int Immunopharmacol. 2023 Dec;125(Pt B):111132._x000D_ 5: Jin X, Wang W, Zhao X, Jiang W, Shao Q, Chen Z, Huang C. The battle between the innate immune cGAS-STING signaling pathway and human herpesvirus infection Front Immunol. 2023 Aug 2;14:1235590._x000D_ 6: An C, Sun F, Liu C, Huang S, Xu T, Zhang C, Ge S. IQGAP1 promotes mitochondrial damage and activation of the mtDNA sensor cGAS-STING pathway to induce endothelial cell pyroptosis leading to atherosclerosis Int Immunopharmacol. 2023 Oct;123:110795._x000D_ 7: Perumal N, White B, Sanchez-Valdez F, Tarleton RL. cGAS-STING Pathway Activation during Trypanosoma cruzi Infection Leads to Tissue-Dependent Parasite Control J Immunol. 2023 Oct 1;211(7):1123-1133._x000D_ 8: Yang CS, Ko TP, Chen CJ, Hou MH, Wang YC, Chen Y. Crystal structure and functional implications of cyclic di-pyrimidine-synthesizing cGAS/DncV-like nucleotidyltransferases Nat Commun. 2023 Aug 21;14(1):5078._x000D_ 9: Zhernakova A, Kurilshikov A, Bonder MJ, Tigchelaar EF, Schirmer M, Vatanen T, Mujagic Z, Vila AV, Falony G, Vieira-Silva S, Wang J, Imhann F, Brandsma E, Jankipersadsing SA, Joossens M, Cenit MC, Deelen P, Swertz MA; LifeLines cohort study; Weersma RK, Feskens EJ, Netea MG, Gevers D, Jonkers D, Franke L, Aulchenko YS, Huttenhower C, Raes J, Hofker MH, Xavier RJ, Wijmenga C, Fu J. Population-based metagenomics analysis reveals markers for gut microbiome composition and diversity Science. 2016 Apr 29;352(6285):565-9._x000D_ <a href="https://pubmed.ncbi.nlm.nih.gov/37225734">10: Van Acker ZP, Perdok A, Hellemans R, North K, Vorsters I, Cappel C, Dehairs J, Swinnen JV, Sannerud R, Bretou M, Damme M, Annaert W. Phospholipase D3 degrades mitochondrial DNA to regulate nucleotide signaling and APP metabolism Nat Commun. 2023 May 24;14(1):2847. </a>_x000D_ _x000D_ <strong>Products Related to cGAS (161-522) Human Recombinant can be found at</strong> <a href="https://moleculardepot.com/product-category/Proteins/"> Proteins</a>