Anti-CD11c(HC1/1), CF405S conjugate
CD11c, also known as Integrin, alpha X (complement component 3 receptor 4 subunit) (ITGAX), is a type I transmembrane protein found at high levels on most human dendritic cells, but also on monocytes, macrophages, neutrophils, and some B cells. It induces cellular activation and helps trigger neutrophil respiratory burst. It is expressed in hairy cell leukemias, acute non-lymphocytic leukemias, and some B-cell chronic lymphocytic leukemias._x000D_ _x000D_ Primary antibodies are available purified, or with a selection of fluorescent CF® Dyes and other labels. CF® Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors._x000D_ _x000D_
Product Specifications
Synonyms
UNSPSC
41116161
UNSPSC Description
Primary and secondary antibodies for multiple methodology immunostaining detection application
Gene Name
ITGAX
Gene ID
3687
NCBI Gene ID
248472
UniProt
P20702
Cellular Locus
Plasma membrane
Host
Mouse
Species Reactivity
Human
Immunogen
Human monocytic U937 phorbol ester-treated cells
Target Antigen
CD11c
Clonality
Monoclonal
Isotype
IgG1 κ
Clone
HC1/1
Conjugation
CF405S
Disease
Tumor
Source
Animal
Applications
Flow (verified) | Flow, surface (published) | Functional studies (published) | IP (published)
Validated Applications
FC,FC,IP
Field of Research
Cell adhesion, Immunology
Positive Control
Human dendritic cells. Human lymph nodes and tonsils.
Concentration
0.1 mg/mL
Buffer
PBS, 0.1% BSA, 0.05% azide
Molecular Weight
145 kDa
Additionnal Information
References & Citations
Shipping Conditions
Room temperature
Storage Conditions
4°C; Protect from light; Stable at room temperature or 37°C (98°F) for 7 days.
Shelf Life
2 years
Product Datasheet
https://cdn.gentaur.com/products/37/866824/datasheet/bnc040152-100.pdf
Product MSDS
https://cdn.gentaur.com/products/37/866824/msds/bnc040152-100.pdf
CAS Number
9007-83-4
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