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Anti-CD10(FR4D11)

CD10 (also known as Common Acute Lymphocytic Leukemia Antigen (CALLA)) is a type II transmembrane protein. It is a cell surface enzyme with neutral metalloendopeptidase activity, which inactivates a variety of biologically active peptides. CD10 is expressed on the cells of lymphoblastic, Burkitt's, and follicular germinal center lymphomas, and on cells from patients with chronic myelocytic leukemia (CML). It is also expressed on the surface of normal early lymphoid progenitor cells, immature B cells within adult bone marrow and germinal center B cells within lymphoid tissue.Primary antibodies are available purified, or with a selection of fluorescent CF® Dyes and other labels. CF® Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.

Product Specifications

Synonyms

CD10; Neprilysin; Atriopeptidase; Common acute lymphocytic leukemia antigen (CALLA); Enkephalinase; gp100; Membrane metalloendopeptidase; Neutral endopeptidase

UNSPSC

41116161

UNSPSC Description

Primary and secondary antibodies for multiple methodology immunostaining detection application

Gene Name

MME

Gene ID

4311

NCBI Gene ID

307734

UniProt

P08473

Cellular Locus

Plasma membrane

Host

Mouse

Species Reactivity

Human

Immunogen

Raji cells

Target Antigen

CD10

Clonality

Monoclonal

Isotype

IgG1 κ

Clone

FR4D11

Conjugation

Purified, with BSA

Disease

Tumor

Source

Animal

Applications

Flow (verified) | Flow, surface (published) | IF (published) | IF (verified)

Validated Applications

FC,FC,IF,IF

Field of Research

Immunology, Proteases

Positive Control

Tonsil, small intestine, kidney

Concentration

0.2 mg/mL

Buffer

PBS, 0.05% BSA, 0.05% azide

Molecular Weight

100 kDa

Additionnal Information

Higher concentration may be required for direct detection using primary antibody conjugates than for indirect detection with secondary antibody|Immunofluorescence: 0.5-1 ug/mL|Flow Cytometry 0.5-1 ug/million cells/0.1 mL|Optimal dilution for a specific application should be determined by user

References & Citations

Note: References for this clone sold by other suppliers may be listed for expected applications. Oncotarget (2015) 6(4): 2315-2330. (Flow, surface) Oncotarget (2016) 7(34): 54157-54173. (IF)

Shipping Conditions

Room temperature

Storage Conditions

4°C; Stable at room temperature or 37°C (98°F) for 7 days.

Shelf Life

2 years

Product Datasheet

https://cdn.gentaur.com/products/37/866244/datasheet/bnub0248-100.pdf

Product MSDS

https://cdn.gentaur.com/products/37/866244/msds/bnub0248-100.pdf

CAS Number

9007-83-4

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