Anti-CD54 / ICAM-1(F4-31C2)
Recognizes an 85-115 kDa protein (variation with cell type), identified as intercellular adhesion molecule (ICAM-1). It has 7 potential N-linked glycosylation sites. ICAM-1 is a single chain glycoprotein of Ig supergene family, present on unstimulated endothelial cells (EC) and on a variety of other cell types including activated fibroblasts, EC, macrophages, and lymphocytes. ICAM-1 mediates cell adhesion by binding to integrins CD11a/CD18 (leukocyte adhesion molecule, LFA-1) and to CD11b/CD18 (Mac-1). This interaction enhances antigen-specific T-cell activation. ICAM-1 also binds to CD43 and to Plasmodium falciparum infected RBCs. ICAM-1 may also be related to progression and metastasis of tumors.
Product Specifications
Synonyms
UNSPSC
41116161
UNSPSC Description
Primary and secondary antibodies for multiple methodology immunostaining detection application
Gene Name
ICAM1
Gene ID
3383
NCBI Gene ID
643447
UniProt
P05362
Cellular Locus
Plasma membrane
Host
Mouse
Species Reactivity
Human
Immunogen
Human umbilical cord vein endothelial cells (HUVEC)
Target Antigen
CD54
Clonality
Monoclonal
Isotype
IgG2a κ
Clone
F4-31C2
Conjugation
Purified, with BSA
Source
Animal
Field of Research
Immunology
Positive Control
Raji cells, MOLT 4, HeLa or SW480 cells. Human tonsil.
Concentration
0.2 mg/mL
Buffer
PBS, 0.05% BSA, 0.05% azide
Molecular Weight
85-115 kDa
Additionnal Information
Shipping Conditions
Room temperature
Storage Conditions
4°C; Stable at room temperature or 37°C (98°F) for 7 days.
Shelf Life
2 years
Product Datasheet
https://cdn.gentaur.com/products/37/862536/datasheet/bnub1249-500.pdf
Product MSDS
https://cdn.gentaur.com/products/37/862536/msds/bnub1249-500.pdf
CAS Number
9007-83-4
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