MRIA9

MRIA9, a chemical probe, is an ATP-competitive, pan Salt-Inducible kinase (SIK) and PAK2/3 inhibitor, with IC50 values of 516 nM, 180 nM and 127 nM for SIK1, SIK2 and SIK3, respectively[1].

Product Specifications

CAS Number

[2750707-05-0]

UNSPSC

12352005

Target

Apoptosis; PAK; Salt-inducible Kinase (SIK)

Type

Reference compound

Related Pathways

Apoptosis; Cell Cycle/DNA Damage; Cytoskeleton; Immunology/Inflammation

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/mria9.html

Purity

98.80

Solubility

DMSO : 66.67 mg/mL (ultrasonic)

Smiles

N[C@@H](CO1)CO[C@H]1CN(C2=O)C3=NC(NC)=NC=C3C=C2C4=CC=C(C=C4Cl)C5=NC=CC=C5F

Molecular Formula

C24H22ClFN6O3

Molecular Weight

496.92

References & Citations

[1]Roberta Tesch, et al. Structure-Based Design of Selective Salt-Inducible Kinase Inhibitors. J Med Chem. 2021 Jun 24;64 (12) :8142-8160.|[2]Monika Raab, et al. The Small-Molecule Inhibitor MRIA9 Reveals Novel Insights into the Cell Cycle Roles of SIK2 in Ovarian Cancer Cells. Cancers 2021, 13 (15), 3658.