PPARδ agonist 11
PPARδ agonist 11 (Compound 11) is a selective agonist for PPARδ with an EC50 of 20 nM. PPARδ agonist 11 reduces the levels of nitrite oxide (NO), proinflammatory cytokines TNFα and IL-6 in LPS (HY-D1056) -stimulated RAW264.7 cell, and exhibits anti-inflammatory efficacy via NF-κB pathway. PPARδ agonist 11 exhibits good stability in human liver microsomes and plasma. PPARδ agonist 11 ameliorates Carrageenan (HY-125474) -induced foot edema[1].
Product Specifications
CAS Number
[2982696-04-6]
UNSPSC
12352005
Target
PPAR
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage; Metabolic Enzyme/Protease; Vitamin D Related/Nuclear Receptor
Applications
COVID-19-anti-virus
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/pparδ-agonist-11.html
Smiles
CC1=CC(SCC(S2)=NN=C2C3=CC=C(C(F)(F)F)C=C3)=CC=C1OCC(O)=O
Molecular Formula
C19H15F3N2O3S2
Molecular Weight
440.46
References & Citations
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
PPARα; PPARβ/δ
Explore Other Products
Discover premium biology products from our extensive collection of 20M+ items
