A-23187 Free Acid

A-23187, also known as Calcimycin or Calcium Ionophore III, is a calcium ionophore that rapidly equilibrates intracellular and extracellular calcium concentrations. It is commonly used for <i>in situ</i> calibrations of fluorescent calcium indicators. The ionophore allows Mn² to enter the cells and quench intracellular fluorescence of calcium indicators. </p> <ul> </p> <li>White solid soluble in DMSO</li> </p> <li>Store at 4°C and protect from light</li> </p> <li>C₂₉H₃₇N₃O₆</li> </p> <li>MW: 523.6</li> </p> <li>[52665-69-7]</li> </p> </ul> </p> Also see 4-bromo A-23187. Because 4-bromo A-23187 is nonfluorescent, it is preferred over the blue fluorescent A-23187 for calibrations of UV-excited Ca² indicators such as Indo-1 and Fura-2 in order to keep background fluorescence to a minimum.