PU02

PU02, a derivative of 6-MP (HY-13677), is a negative allosteric modulator (NAM) of 5-HT3 receptor, with IC50 values of 0.36 and 0.73 μM in HEK293 cells transfected with human 5-HT3A and 5-HT3AB receptors respectively[1][2].

Product Specifications

CAS Number

[313984-77-9]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

5-HT Receptor; Apoptosis

Type

Reference compound

Related Pathways

Apoptosis; GPCR/G Protein; Neuronal Signaling

Applications

Cancer-programmed cell death

Field of Research

Cancer; Neurological Disease

Assay Protocol

https://www.medchemexpress.com/pu02.html

Purity

99.76

Solubility

DMSO : 250 mg/mL (ultrasonic)

Smiles

C12=NC=NC(SCC3=C4C=CC=CC4=CC=C3)=C1N=CN2

Molecular Formula

C16H12N4S

Molecular Weight

292.36

Precautions

H302, H315, H319, H335

References & Citations

[1]Sarah M Trattnig, et al. Discovery of a novel allosteric modulator of 5-HT3 receptors: inhibition and potentiation of Cys-loop receptor signaling through a conserved transmembrane intersubunit site. J Biol Chem. 2012 Jul 20;287 (30) :25241-54.|[2]Xiao-Guang Yang, et al. 6-[ (1-naphthylmethyl) sulfanyl]-9H-purine induces G2/M phase arrest and apoptosis in human hepatocellular carcinoma HepG2 cells. Eur J Pharmacol. 2012 Nov 15;695 (1-3) :27-33.