ALK5-IN-83

ALK5-IN-83 (compound 13b) is a ALK5 inhibitor with the IC50 of 0.13 μM. ALK5-IN-83 inhibits TGF-β1-induced Smad2 phosphorylation and cell motility in A549 cells[1].

Product Specifications

UNSPSC

12352005

Target

TGF-beta/Smad

Type

Reference compound

Related Pathways

Stem Cell/Wnt; TGF-beta/Smad

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/alk5-in-83.html

Smiles

CCCCS(=O)(NCC1=NC(C2=CN3N=CN=C3C=C2)=C(N1)C4=CC=CC(C)=N4)=O

Molecular Formula

C20H23N7O2S

Molecular Weight

425.51

References & Citations

[1]Ding SY, et al. Synthesis and biological evaluation of sulfonamide derivatives containing imidazole moiety as ALK5 inhibitors. Mol Divers. 2024 Aug 30.