AS-041164

AS-041164 is a potent, selective and orally active PI3Kγ isoform inhibitor with an IC50 of 70 nM. AS-041164 shows less activity against PI3Kα, PI3Kβ, and PI3Kδ (IC50s of 240 nM, 1.45 μM, and 1.70 μM, respectively) . AS-041164 has anti-inflammatory effects[1].

Product Specifications

CAS Number

[6318-41-8]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

PI3K

Type

Reference compound

Related Pathways

PI3K/Akt/mTOR

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/as-041164.html

Purity

99.02

Solubility

DMSO : 125 mg/mL (ultrasonic)

Smiles

O=C(N1)/C(SC1=O)=C/C2=CC=C3C(OCO3)=C2

Molecular Formula

C11H7NO4S

Molecular Weight

249.24

Precautions

H302, H315, H319, H335

References & Citations

[1]Chiara Ferrandi, et al. Phosphoinositide 3-kinase gamma inhibition plays a crucial role in early steps of inflammation by blocking neutrophil recruitment. J Pharmacol Exp Ther. 2007 Sep;322 (3) :923-30.