2-Hydroxyisoquinoline-1,3(2H,4H)-dione
Product Specifications
UNSPSC Description
Hydroxyisoquinoline-1,3(2H,4H)-dione (compound 6a) is a HIV-1 integrase (IN) and HIV-1 reverse transcriptase (RT) ribonuclease H (RNase H) inhibitor with an IC50 value of 6.32, 5.9 µM, respectively[1].
Target Antigen
HIV Integrase
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Field of Research
Infection
Assay Protocol
https://www.medchemexpress.com/2-hydroxyisoquinoline-1-3-2h-4h-dione.html
Smiles
C1=CC=C2C(=C1)CC(=O)N(C2=O)O
Molecular Weight
177.16
References & Citations
[1]Billamboz M, et al. Design, synthesis, and biological evaluation of a series of 2-hydroxyisoquinoline-1,3(2H,4H)-diones as dual inhibitors of human immunodeficiency virus type 1 integrase and the reverse transcriptase RNase H domain. J Med Chem. 2008 Dec 25;51(24):7717-30.
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-W103287/2-Hydroxyisoquinoline-1-3-2H-4H-dione-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-W103287/
Clinical Information
No Development Reported
CAS Number
6890-08-0
Curated Selection
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