Recombinant Human Alpha-1-Antitrypsin

Product Specifications

CAS Number

9000-83-3

Product Name Alternative

A1AT

UniProt

P01009

Reactivity

Human

Target Antigen

Alpha-1-antitrypsin

Target

Alpha-1-Antitrypsin

Type

Protein

Applications

Concentration

Lot Specific

Dilution

Dilute in PBS or medium that is identical to that used in the assay system.

Form

Liquid

Buffer

20 mM Tris

Storage Conditions

Although stable at 4°C for 4 weeks, product is best stored at or below -20°C. For long-term storage, addition of a carrier protein (such as 0.1% HSA or BSA) is recommended. For in vitro investigational use only.

Specificity

Alpha-1-Antitrypsin

Formulation

Sterile-filtered colorless solution contains 20mM Tris-HCl, pH 7.5, 1mM DTT, 10% glycerol, and 2mM EDTA.

Buffer pH

pH 7.5

Target Background

Alpha-1-antitrypsin (A1AT) is a serine protease inhibitor that inhibits the catalytic domain of elastase, plasmin, collagenase, thrombin, leucocytic proteases, trypsin, chymotrypsin, and plasminogen activator. Defects in the A1AT gene can lead to emphysema or liver disease. Increased levels of serum A1AT are found in cases of lung and prostate cancers and as an acute phase response to tissue necrosis and inflammation.