Trihexyphenidyl

Trihexyphenidyl is a potent and selective M1 muscarinic receptor antagonist. Trihexyphenidyl shows anticholinergic activity, and can be used for Parkinson syndrome or dystonia research[1][2].

Product Specifications

CAS Number

[144-11-6]

UNSPSC

12352005

Hazard Statement

H315-H319-H320

Target

Cholinesterase (ChE) ; mAChR

Type

Reference compound

Related Pathways

GPCR/G Protein; Neuronal Signaling

Applications

Neuroscience-Neurodegeneration

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/trihexyphenidyl.html

Solubility

10 mM in DMSO

Smiles

OC(C1=CC=CC=C1)(C2CCCCC2)CCN3CCCCC3

Molecular Formula

C20H31NO

Molecular Weight

301.47

Precautions

P264-P280-P302+P352-P305+P351+P338-P362

References & Citations

[1]Giachetti A, et al. Binding and functional profiles of the selective M1 muscarinic receptor antagonists trihexyphenidyl and dicyclomine. Br J Pharmacol. 1986 Sep;89 (1) :83-90. |[2]Jilani TN, et al. Trihexyphenidyl. 2022 Feb 27. In: StatPearls [Internet]. Treasure Island (FL) : StatPearls Publishing; 2022 Jan–.