EGFR T790M/L858R-IN-5
EGFR T790M/L858R-IN-5 (example 52) is a potent inhibitor of EGFR T790M/L858R with the inhibition percentage of 92.9% in the concerntration of 0.05 μM[1].
Product Specifications
CAS Number
3032760-70-3
UNSPSC
12352005
Target
EGFR
Type
Reference compound
Related Pathways
JAK/STAT Signaling; Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/egfr-t790m-l858r-in-5.html
Solubility
10 mM in DMSO
Smiles
CN1C=C(C2=CC=NC(NC3=C(OC)C=C(NCCN(C)C)C(NC4=NC=NC=C4)=C3)=N2)C5=C1C=CC=C5
Molecular Formula
C28H31N9O
Molecular Weight
509.61
References & Citations
[1]dvenchen Pharmaceuticals, LLC. Preparation of pyrimidine compound as kinase inhibitors with biological activities on EGFR mutants. World Intellectual Property Organization, WO2024064091 A1 2024-03-28
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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