VU-1545

VU-1545 is a metabotropic glutamate receptor 5 positive allosteric modulator (mGluR5 PAM) with a Ki of 156 nM and an EC50 of 9.6 nM[1].

Product Specifications

CAS Number

[890764-63-3]

UNSPSC

12352005

Target

MGluR

Type

Reference compound

Related Pathways

GPCR/G Protein; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/vu-1545.html

Purity

99.00

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

O=C(NC1=CC(C2=CC=CC=C2)=NN1C3=CC=CC=C3F)C4=CC=C([N+]([O-])=O)C=C4

Molecular Formula

C22H15FN4O3

Molecular Weight

402.38

References & Citations

[1]Tomas de Paulis, et al. Substituent effects of N- (1,3-diphenyl-1H-pyrazol-5-yl) benzamides on positive allosteric modulation of the metabotropic glutamate-5 receptor in rat cortical astrocytes. J Med Chem. 2006 Jun 1;49 (11) :3332-44.|[2]J G Doria, et al. Metabotropic glutamate receptor 5 positive allosteric modulators are neuroprotective in a mouse model of Huntington's disease. Br J Pharmacol. 2013 Jun;169 (4) :909-21.