OX40/TNFRSF4, Cynomolgus (HEK293, His)

Product Specifications

UNSPSC Description

OX40 (TNFRSF4), is a receptor for OX40 Ligand. OX40 is preferentially expressed by T cells. OX40 can be activated by OX40 Ligand, thereby functioning as a T cell co-stimulatory molecule. The OX40-OX40 Ligand interaction promotes effector T-cell survival and effectively induces memory T-cell generation, as well as enhances the helper function of Tfh for B cells, and also promotes the differentiation and maturation of DCs[1][2]. OX40/TNFRSF4 Protein, Rhesus Macaque (HEK293, Fc) is a recombinant cynomolgus OX40 (K28-A216) with C-terminal 6*His tag, which is produced in HEK293.

Type

Recombinant Proteins

Assay Protocol

https://www.medchemexpress.com/cytokines/ox40-protein-cynomolgus-hek-293-his.html

Purity

95.0

Smiles

KLHCVGDTYP SNDRCCQECR PGNGMVSRCN RSQNTVCRPC GPGFYNDVVS AKPCKACTWC NLRSGSERKQ PCTATQDTVC RCRAGTQPLD SYKPGVDCAP CPPGHFSPGD NQACKPWTNC TLAGKHTLQP ASNSSDAICE DRDPPPTQPQ ETQGPPARPT TVQPTEAWPR TSQRPSTRPV EVPRGPA

Molecular Weight

35-50 kDa

References & Citations

[1]Kaur D, et al. OX40/OX40 ligand interactions in T-cell regulation and asthma. Chest. 2012 Feb;141(2):494-499.|[2]Fu N, et al. The OX40/OX40L Axis Regulates T Follicular Helper Cell Differentiation: Implications for Autoimmune Diseases. Front Immunol. 2021 Jun 21;12:670637.|[3]Buglio D, et al. HDAC11 plays an essential role in regulating OX40 ligand expression in Hodgkin lymphoma. Blood. 2011 Mar 10;117(10):2910-7.|[4]Kotani A, et al. Signaling of gp34 (OX40 ligand) induces vascular endothelial cells to produce a CC chemokine RANTES/CCL5. Immunol Lett. 2002 Oct 21;84(1):1-7.