TB114
MDM2-IN-27 targets MDM2 protein (Ki = 0.4 nM) . MDM2-IN-27 activates the anti-tumor activity of p53 and induces apoptosis by blocking the negative regulation of p53 by MDM2[1].
Product Specifications
CAS Number
[3058605-06-1]
UNSPSC
12352005
Target
MDM-2/p53
Type
Reference compound
Related Pathways
Apoptosis
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/mdm2-in-27.html
Solubility
10 mM in DMSO
Smiles
ClC1=CC([C@@H]2[C@@]3(C4=CC=C(Cl)C=C4NC3)[C@H](CC(C)(C)C)N5[C@H]2C(N(C5)C6=C(OC)C=C(C(O)=O)C=C6)=O)=CC=C1
Molecular Formula
C32H33Cl2N3O4
Molecular Weight
594.53
References & Citations
[1]Lin Z, et al. Synthesis and biological evaluation of 4-imidazolidinone-containing compounds as potent inhibitors of the MDM2/p53 interaction. Eur J Med Chem. 2024 Apr 15;270:116366.
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-162432/MDM2-IN-27-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-162432/
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Curated Selection
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