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EM20-25

EM20-25 is an inhibitor for Bcl-2, which interferes with the interaction between BCL-2 and BAX, activates caspase-9 and thus induces the apoptosis. EM20-25 affects the mitochondrial function, causes the open of permeability transition pore (PTP) . EM20-25 enhances the sensitivity of cells to Staurosporine (HY-15141), and enhances the killing effect of BCL-2-expressing leukemia cells to Chlorambucil (HY-13593) and Fludarabine (HY-B0069) [1].

Product Specifications

CAS Number

[141266-44-6]

UNSPSC

12352005

Hazard Statement

H400

Target

Apoptosis; Bcl-2 Family; Caspase

Type

Reference compound

Related Pathways

Apoptosis

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/em20-25.html

Smiles

O=C1NC(C(C2C3=CC(Cl)=CC=C3OC(NC(N4)=O)=C2C4=O)C(N1)=O)=O

Molecular Formula

C15H9ClN4O6

Molecular Weight

376.71

Precautions

P273-P391-P501

References & Citations

[1]Milanesi E, et al., The mitochondrial effects of small organic ligands of BCL-2: sensitization of BCL-2-overexpressing cells to apoptosis by a pyrimidine-2,4,6-trione derivative. J Biol Chem. 2006 Apr 14;281 (15) :10066-72.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Isoform

Caspase 9

Curated Selection

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