EM20-25
Product Specifications
UNSPSC Description
EM20-25 is an inhibitor for Bcl-2, which interferes with the interaction between BCL-2 and BAX, activates caspase-9 and thus induces the apoptosis. EM20-25 affects the mitochondrial function, causes the open of permeability transition pore (PTP). EM20-25 enhances the sensitivity of cells to Staurosporine (HY-15141), and enhances the killing effect of BCL-2-expressing leukemia cells to Chlorambucil (HY-13593) and Fludarabine (HY-B0069)[1].
Target Antigen
Apoptosis; Bcl-2 Family; Caspase
Type
Reference compound
Related Pathways
Apoptosis
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/em20-25.html
Smiles
O=C1NC(C(C2C3=CC(Cl)=CC=C3OC(NC(N4)=O)=C2C4=O)C(N1)=O)=O
Molecular Weight
376.71
References & Citations
[1]Milanesi E, et al., The mitochondrial effects of small organic ligands of BCL-2: sensitization of BCL-2-overexpressing cells to apoptosis by a pyrimidine-2,4,6-trione derivative. J Biol Chem. 2006 Apr 14;281(15):10066-72.
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-101999/EM20-25-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-101999/
Clinical Information
No Development Reported
CAS Number
141266-44-6
Curated Selection
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