SLV310

SLV310 is an orally active dopamine D2 receptor antagonist (Ki: 5 nM) and serotonin reuptake receptor inhibitor. SLV310 antagonizes Apomorphine (HY-12723) induced climbing behaviour and 5-HTP (HY-N0122) induced serotonin syndrome like behaviour in mice (ED50: 5.6 and 5.9 mg/kg, p.o.) . SLV310 is an antipsychotic compound and can be used for schizophrenia research[1].

Product Specifications

CAS Number

[264869-71-8]

UNSPSC

12352005

Target

Dopamine Receptor; Serotonin Transporter

Type

Reference compound

Related Pathways

GPCR/G Protein; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/slv310.html

Smiles

O=C1C2=C(C(N1CCCCN3CC=C(CC3)C4=CNC5=C4C=C(F)C=C5)=O)C=CC=C2

Molecular Formula

C25H24FN3O2

Molecular Weight

417.48

References & Citations

[1]van Hes R, et al. SLV310, a novel, potential antipsychotic, combining potent dopamine D2 receptor antagonism with serotonin reuptake inhibition. Bioorg Med Chem Lett. 2003 Feb 10;13 (3) :405-8.