(25S)-Δ7-Dafachronic acid
Product Specifications
UNSPSC Description
(25S)-Δ7-Dafachronic acid is a ligand and activator of DAF-12 receptor. DAF-12 is a nuclear hormone receptor that regulates larval diapause, developmental age, and adult longevity in Caenorhabditis elegans[1][2][3].
Target Antigen
Others
Type
Reference compound
Related Pathways
Others
Field of Research
Others
Assay Protocol
https://www.medchemexpress.com/25s-7-dafachronic-acid.html
Solubility
10 mM in DMSO
Smiles
C[C@@]12[C@](CC[C@]2([H])[C@H](C)CCC[C@H](C)C(O)=O)([H])C3=CC[C@](CC(CC4)=O)([H])[C@@]4(C)[C@@]3([H])CC1
Molecular Weight
414.62
References & Citations
[1]|[2]Martin R,et al. Stereoselective synthesis of the hormonally active (25S)-delta7-dafachronic acid, (25S)-Delta4-dafachronic acid, (25S)-dafachronic acid, and (25S)-cholestenoic acid. Org Biomol Chem. 2008 Dec 7;6(23):4293-5. |[3]Sharma KK, et al. Synthesis and activity of dafachronic acid ligands for the C. elegans DAF-12 nuclear hormone receptor. Mol Endocrinol. 2009 May;23(5):640-8. |[4]Ma G, et al. Dafachronic acid promotes larval development in Haemonchus contortus by modulating dauer signalling and lipid metabolism. PLoS Pathog. 2019 Jul 23;15(7):e1007960.
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-130221/25S-7-Dafachronic-acid-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-130221/
Clinical Information
No Development Reported
CAS Number
949004-12-0
Curated Selection
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