WYRGRL

WYRGRL, a collagen II-targeting peptide, can bind to collagen II α1. WYRGRL is a short cartilage-targeting peptide sequence. WYRGRL leads to about 72-fold increase of cartilage-targeting efficiency for the peptide-functionalized nanoplatform in vivo[1][2].

Product Specifications

CAS Number

[1021155-39-4]

UNSPSC

12352209

Target

MMP

Type

Peptides

Related Pathways

Metabolic Enzyme/Protease

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/wyrgrl.html

Purity

99.88

Solubility

DMSO : 50 mg/mL (ultrasonic)

Smiles

O=C(N[C@@H](CC1=CC=C(C=C1)O)C(N[C@@H](CCCNC(N)=N)C(NCC(N[C@@H](CCCNC(N)=N)C(N[C@@H](CC(C)C)C(O)=O)=O)=O)=O)=O)[C@H](CC2=CNC3=CC=CC=C23)N

Molecular Formula

C40H59N13O8

Molecular Weight

849.98

References & Citations

[1]Kai Ren, et al. Zwitterionic polymer modified xanthan gum with collagen II-binding capability for lubrication improvement and ROS scavenging. Carbohydr Polym. 2021 Nov 15:274:118672. |[2]Dominique A Rothenfluh, et al. Biofunctional polymer nanoparticles for intra-articular targeting and retention in cartilage. Nat Mater. 2008 Mar;7 (3) :248-54.