Fenoprofen

Fenoprofen (LILLY-53858) is a nonsteroidal anti-inflammatory agent (NSAID) and inhibits cyclooxygenase (COX) . Fenoprofen is a melanocortin receptors (MCRs) positive allosteric modulator (PAM) . Fenoprofen also increases ERK1/2 activation in HEK293T cells. Fenoprofen has anti-arthritic activities and can be used for the study of rheumatoid arthritis and osteoarthritis[1][2].

Product Specifications

CAS Number

[29679-58-1]

Product Name Alternative

LILLY-53858

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

COX; ERK; Melanocortin Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein; Immunology/Inflammation; MAPK/ERK Pathway; Neuronal Signaling; Stem Cell/Wnt

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/fenoprofen.html

Purity

99.70

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

O=C(O)C(C)C1=CC=CC(OC2=CC=CC=C2)=C1

Molecular Formula

C15H14O3

Molecular Weight

242.27

Precautions

H302, H315, H319, H335

References & Citations

[1]Montero-Melendez T, et al. Old drugs with new skills: fenoprofen as an allosteric enhancer at melanocortin receptor 3. Cell Mol Life Sci. 2017 Apr;74 (7) :1335-1345.|[2]Xiao-Chen Yuan, et al. Fenoprofen-An Old Drug Rediscovered as a Biased Allosteric Enhancer for Melanocortin Receptors. ACS Chem Neurosci. 2019 Mar 20;10 (3) :1066-1074.