TNF-α-IN-19
Product Specifications
UNSPSC Description
TNF-α-IN-19 is an inhibitor of TNFα that can block the interaction between TNFαRI, TRADD, and RIP1, the EC50 values for TNFα, IL-1β, and IL-1β/TNFα are 2.451, 3.792 and 1.54 μM, respectively. TNF-α-IN-19 only inhibits the degradation of IκBα when cells are stimulated by TNFα and not by IL-1β[1].
Target Antigen
IKK; Interleukin Related; RIP kinase; TNF Receptor
Type
Reference compound
Related Pathways
Apoptosis;Immunology/Inflammation;NF-κB
Field of Research
Others
Assay Protocol
https://www.medchemexpress.com/tnf-α-in-19.html
Smiles
ClC1=CC=C(C2=NN=C3N2C4=C(N=C3C(F)(F)F)C=CC=C4)C=C1
Molecular Weight
348.71
References & Citations
[1]Tarikere L. Gururaja, et al. A Class of SmallMolecules thatInhibit TNFa-Induced Survival and Death Pathways via Prevention of Interactions between TNFaRI, TRADD, and RIP1. Chemistry & Biology. 2007; 14(10), 1105–1118.
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-114573/TNF-α-IN-19-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-114573/
Clinical Information
No Development Reported
CAS Number
338773-13-0
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