p,p'-DDE-d8
Product Specifications
UNSPSC Description
p,p'-DDE-d8 is the deuterium labeled p,p'-DDE[1]. p,p'-DDE (4,4'-DDE), a major metabolite of persistent dichlorodiphenyltrichloroethane (DDT), is a potent androgen receptor antagonist, with an IC50 of 5 μM and a Ki of 3.5 μM[2].
Target Antigen
Androgen Receptor; Drug Metabolite
Type
Isotope-Labeled Compounds
Related Pathways
Metabolic Enzyme/Protease;Vitamin D Related/Nuclear Receptor
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Endocrinology
Solubility
10 mM in DMSO
Smiles
Cl/C(Cl)=C(C1=C([2H])C([2H])=C(C([2H])=C1[2H])Cl)/C2=C([2H])C([2H])=C(C([2H])=C2[2H])Cl
Molecular Weight
326.07
References & Citations
[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216.|[2]Kelce WR, et al. Persistent DDT metabolite p,p'-DDE is a potent androgen receptor antagonist. Nature. 1995;375(6532):581-585.
Shipping Conditions
Room temperature
Clinical Information
No Development Reported
CAS Number
93952-19-3
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