Fenobucarb

Fenobucarb is a carbamate insecticide. Fenobucarb induces zebrafish developmental neurotoxicity through pathways involved in inflammation, oxidative stress, degeneration and apoptosis. Fenobucarb is a possible risk factor to cardiovascular and cerebrovascular systems in animals[1][2].

Product Specifications

CAS Number

[3766-81-2]

UNSPSC

12352005

Hazard Statement

H302, H400

Target

Apoptosis; Caspase; Cholinesterase (ChE) ; Reactive Oxygen Species (ROS)

Type

Reference compound

Related Pathways

Apoptosis; Immunology/Inflammation; Metabolic Enzyme/Protease; Neuronal Signaling; NF-κB

Applications

Neuroscience-Neuromodulation

Field of Research

Inflammation/Immunology; Neurological Disease; Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/fenobucarb.html

Purity

98.30

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

CCC(C1=CC=CC=C1OC(NC)=O)C

Molecular Formula

C12H17NO2

Molecular Weight

207.27

Precautions

H302, H400

References & Citations

[1]Xiao-Yu Zhu, et al. Fenobucarb-induced developmental neurotoxicity and mechanisms in zebrafish. Neurotoxicology. 2020 Jul;79:11-19.|[2]Xiao-Yu Zhu, et al. Fenobucarb induces heart failure and cerebral hemorrhage in zebrafish. Aquat Toxicol. 2019 Apr;209:34-41.