Flurofamide

Flurofamide is an effective bacterial urease inhibitor and antibacterial agent. Flurofamide inhibits urease and partially inhibits the chemotactic activity of Helicobacter pylori strain CPY3401. Flurofamide inhibits the growth of Ureaplasma urealyticum. Flurofamide reduces blood ammonia. Flurofamide can be used in the research of infectious urinary stones[1][2][3][4].

Product Specifications

CAS Number

[70788-28-2]

UNSPSC

12352005

Target

Bacterial; Urease

Type

Reference compound

Related Pathways

Anti-infection

Applications

Neuroscience-Neuromodulation

Field of Research

Infection; Metabolic Disease

Assay Protocol

https://www.medchemexpress.com/flurofamide.html

Purity

92.6

Solubility

DMSO : 14.29 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

O=C(NP(N)(N)=O)C1=CC=C(F)C=C1

Molecular Formula

C7H9FN3O2P

Molecular Weight

217.14

References & Citations

[1]Millner OE Jr, et al. Flurofamide: a potent inhibitor of bacterial urease with potential clinical utility in the treatment of infection induced urinary stones. J Urol. 1982 Feb;127 (2) :346-50.|[2]Fleming D, et al. Flurofamide Prevention and Treatment of Ureaplasma-Induced Hyperammonemia. Microbiol Spectr. 2022 Oct 26;10 (5) :e0192722.|[3]Nakamura H, et al. Urease plays an important role in the chemotactic motility of Helicobacter pylori in a viscous environment. Infect Immun. 1998 Oct;66 (10) :4832-7. |[4]Kenny GE. Inhibition of the growth of Ureaplasma urealyticum by a new urease inhibitor, flurofamide. Yale J Biol Med. 1983 Sep-Dec;56 (5-6) :717-22.