ZD06519

ZD06519 (7-Hydroxyethyl carbamate- (10Me-11F-Camptothecin) ) is a camptothecin (HY-16560) analogue and a topoisomerase I inhibitor. ZD06519 is an ADC cytotoxin with a strong bystander effect, inhibiting a variety of malignancies such as HER2-positive and FRα-overexpressing tumors. ZD06519 inhibits DNA cleavage, relaxation, and reconnection processes, inducing tumor cell death. ZD06519 can be used for ADC synthesis and cancer research[1][2].

Product Specifications

CAS Number

[2873460-17-2]

Product Name Alternative

7-Hydroxyethyl carbamate- (10Me-11F-Camptothecin)

UNSPSC

12352203

Target

ADC Payload

Type

ADC Related

Related Pathways

Antibody-drug Conjugate/ADC Related

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/7-hydroxyethyl-carbamate-10me-11f-camptothecin.html

Purity

98.88

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

O=C1N2C(C(C(C2)=C(C3=C4)CNC(OCCO)=O)=NC3=CC(F)=C4C)=CC5=C1COC([C@]5(O)CC)=O

Molecular Formula

C25H24FN3O7

Molecular Weight

497.47

References & Citations

[1]Mark Edmund PETERSEN, et al. Camptothecin analogues, conjugates and methods of use. Patent. WO2022246576.|[2]Petersen ME, et al. Design and Evaluation of ZD06519, a Novel Camptothecin Payload for Antibody Drug Conjugates. Mol Cancer Ther. 2024 May 2;23 (5) :606-618.