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Ametantrone (acetate)

Ametantrone acetate (NSC 196473 acetate) is an antineoplastic drug with topoisomerase II inhibitory activity. Ametantrone acetate causes covalent cross-linking of DNA. The pharmacokinetic profile of Ametantrone acetate has been confirmed in clinical trials, and its elimination pathway in the body indicates the existence of a major metabolic pathway[1].

Product Specifications

CAS Number

[70711-40-9]

Product Name Alternative

NSC 196473 (acetate) ; NSC 290813 (acetate)

UNSPSC

12352005

Target

DNA/RNA Synthesis

Type

Reference compound

Related Pathways

Cell Cycle/DNA Damage

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/ametantrone-acetate.html

Smiles

O=C1C2=C(C(C3=C(C=CC(NCCNCCO)=C13)NCCNCCO)=O)C=CC=C2.CC(O)=O.CC(O)=O

Molecular Formula

C26H36N4O8

Molecular Weight

532.59

References & Citations

[1]Lee CH, et al. Anthracenedione-methionine conjugates are novel topoisomerase II-targeting anticancer agents with favorable drug resistance profiles. Biochem Pharmacol. 2012;83 (9) :1208-1216. |[2]Pharmacokinetics of ametantrone acetate (NSC-287513)

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Curated Selection

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