A-381393

A-381393 is a potent, selective, brain penetrate dopamine D4 receptor antagonist, with Kis of 1.5, 1.9 and 1.6 nM for human dopamine D4.4, D4.2, and D4.7 receptor, respectively, >2700-fold selectivity over D1, D2, D3 and D5 dopamine receptors. A-381393 shows moderate affinity for 5-HT2A (Ki, 370 nM) [1].

Product Specifications

CAS Number

[726174-00-1]

Product Name Alternative

Bisdesethylchloroquine,Bisdesethylchloroquine-d13

UNSPSC

12352005

Hazard Statement

H315, H319

Target

Dopamine Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/A-381393.html

Purity

99.92

Solubility

DMSO : 51.67 mg/mL (ultrasonic)

Smiles

CC1=CC=C(C=C1C)N2CCN(CC2)CC3=NC4=CC=CC=C4N3

Molecular Formula

C20H24N4

Molecular Weight

320.43

Precautions

H315, H319

References & Citations

[1]Nakane M, et al. 2-[4- (3,4-Dimethylphenyl) piperazin-1-ylmethyl]-1H benzoimidazole (A-381393), a selective dopamine D4 receptor antagonist. Neuropharmacology. 2005 Jul;49 (1) :112-21.