Kira8

Kira8 (AMG-18) is a mono-selective IRE1α inhibitor that allosterically attenuates IRE1α RNase activity with an IC50 of 5.9 nM[1].

Product Specifications

CAS Number

[1630086-20-2]

Product Name Alternative

AMG-18

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

IRE1

Type

Reference compound

Related Pathways

Cell Cycle/DNA Damage

Applications

COVID-19-anti-virus

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/Kira8.html

Purity

98.90

Solubility

DMSO : 65 mg/mL (ultrasonic) |Ethanol : 76.92 mg/mL (ultrasonic; adjust pH to 5 with HCl) |H2O : 30 mg/mL (ultrasonic; warming; adjust pH to 2 with HCl; heat to 60°C)

Smiles

O=S(C1=CC=CC=C1Cl)(NC2=C3C=CC(C)=C(OC4=NC=CC=C4C5=NC(N[C@@H]6CNCCC6)=NC=C5)C3=CC=C2)=O

Molecular Formula

C31H29ClN6O3S

Molecular Weight

601.12

Precautions

H302, H315, H319, H335

References & Citations

[1]Morita S, et al. Targeting ABL-IRE1α Signaling Spares ER-Stressed Pancreatic β Cells to Reverse Autoimmune Diabetes. Cell Metab. 2017 Apr 4;25 (4) :883-897.e8.