Kira8
Kira8 (AMG-18) is a mono-selective IRE1α inhibitor that allosterically attenuates IRE1α RNase activity with an IC50 of 5.9 nM[1].
Product Specifications
CAS Number
[1630086-20-2]
Product Name Alternative
AMG-18
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
IRE1
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage
Applications
COVID-19-anti-virus
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/Kira8.html
Purity
98.90
Solubility
DMSO : 65 mg/mL (ultrasonic) |Ethanol : 76.92 mg/mL (ultrasonic; adjust pH to 5 with HCl) |H2O : 30 mg/mL (ultrasonic; warming; adjust pH to 2 with HCl; heat to 60°C)
Smiles
O=S(C1=CC=CC=C1Cl)(NC2=C3C=CC(C)=C(OC4=NC=CC=C4C5=NC(N[C@@H]6CNCCC6)=NC=C5)C3=CC=C2)=O
Molecular Formula
C31H29ClN6O3S
Molecular Weight
601.12
Precautions
H302, H315, H319, H335
References & Citations
[1]Morita S, et al. Targeting ABL-IRE1α Signaling Spares ER-Stressed Pancreatic β Cells to Reverse Autoimmune Diabetes. Cell Metab. 2017 Apr 4;25 (4) :883-897.e8.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Curated Selection
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