Perospirone

Perospirone (SM-9018 free base) is an orally active antagonist of 5-HT2A receptor (Ki=0.6 nM) and dopamine D2 receptor (Ki=1.4 nM), and also a partial agonist of 5-HT1A receptor (Ki=2.9 nM) . Perospirone is an atypical antipsychotic agent and has the potential for schizophrenic disease research[1][2].

Product Specifications

CAS Number

[150915-41-6]

Product Name Alternative

SM-9018 (free base)

UNSPSC

12352005

Target

5-HT Receptor; Dopamine Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/perospirone.html

Concentration

10mM

Purity

99.03

Solubility

DMSO : 5 mg/mL (ultrasonic)

Smiles

O=C([C@@]1([H])[C@]2([H])CCCC1)N(C2=O)CCCCN3CCN(C4=NSC5=C4C=CC=C5)CC3

Molecular Formula

C23H30N4O2S

Molecular Weight

426.57

References & Citations

[1]Kato T, et al. Binding profile of SM-9018, a novel antipsychotic candidate. pn J Pharmacol. 1990 Dec;54 (4) :478-81.|[2]Hagiwara H, et al. Phencyclidine-induced cognitive deficits in mice are improved by subsequent subchronic administration of the antipsychotic drug perospirone: role of serotonin 5-HT1A receptors. Eur Neuropsychopharmacol. 2008 Jun;18 (6) :448-54.