Niemann Pick C1/NPC1, Human (His)

The Niemann Pick C1/NPC1 protein is an intracellular cholesterol transporter that cooperates with NPC2 to promote cholesterol efflux from the endosomal/lysosomal compartment. NPC2 transfers unesterified cholesterol to the N-terminal domain of NPC1, where the cholesterol is bound in a hydrophobic pocket. Niemann Pick C1/NPC1 Protein, Human (His-Flag) is the recombinant human-derived Niemann Pick C1/NPC1 protein, expressed by HEK293 , with N-His labeled tag. The total length of Niemann Pick C1/NPC1 Protein, Human (His-Flag) is 251 a.a., with molecular weight of ~38-55 kDa.

RVTTNPVDLW SAPSSQARLE KEYFDQHFGP FFRTEQLIIR APLTDKHIYQ PYPSGADVPF GPPLDIQILH QVLDLQIAIE NITASYDNET VTLQDICLAP LSPYNTNCTI LSVLNYFQNS HSVLDHKKGD DFFVYADYHT HFLYCVRAPA SLNDTSLLHD PCLGTFGGPV FPWLVLGGYD DQNYNNATAL VITFPVNNYY NDTEKLQRAQ AWEKEFINFV KNYKNPNLTI SFTAERSIED ELNRESDSDV F