Omesdafexor
Product Specifications
UNSPSC Description
Omesdafexor (MET642) is an oral FXR agonist. Omesdafexor can improve colitis induced by adoptive T cell transfer，promote intestinal antimicrobial function, barrier function and inhibit inflammation [1][2][3].
Target Antigen
FXR
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Metabolism-sugar/lipid metabolism
Field of Research
Cancer; Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/omesdafexor.html
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
CC(C=C1[C@@H](CC2)CC[C@H]2CN(C3=CC(C4=CN(C5CC5)N=C4)=CC=C3)C([C@@H]6CC[C@H](CC6)O)=O)=C(C=C1)OC
Molecular Weight
541.72
References & Citations
[1]https://cdn.who.int/media/docs/default-source/international-nonproprietary-names-(inn)/pl127.pdf?sfvrsn=8544ca1e_3&download=true|[2]Xueqing Liu, et al. COMBINATION OF FXR AGONIST MET642 WITH TOFACITINIB EXHIBITS SYNERGISTIC EFFECTS IN IMPROVING COLITIS IN ADOPTIVE T-CELL TRANSFER IBD MODEL. METACRINE.|[3]Xueqing Liu, et al. P153 MET642, AN ORAL FXR AGONIST, IMPROVES COLITIS INDUCED BY ADOPTIVE T-CELL TRANSFER. Volume 158, Issue 3, Supplement S11February 2020.
Shipping Conditions
Room Temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-147296/Omesdafexor-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-147296/Omesdafexor-SDS-MedChemExpress.pdf
Clinical Information
Phase 2
CAS Number
2244440-85-3
Available Sizes
Curated Selection
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