P53 Activator 5

P53 Activator 5 (compound 134A) is a potent p53 activator with a SC150 value of [1]. p53 Activator 5 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

Product Specifications

CAS Number

[2636840-37-2]

UNSPSC

12352005

Target

MDM-2/p53

Type

Reference compound

Related Pathways

Apoptosis

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/p53-activator-5.html

Purity

98.43

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

COC1=CC(C(F)(F)F)=CC=C1NCC#CC2=CC3=C(C=CC=C3N[C@@H](CC4)CC[C@H]4N(C)C)N2CC(F)(F)F

Molecular Formula

C29H32F6N4O

Molecular Weight

566.58

References & Citations

[1]VU, Binh, et al. Methods and compounds for restoring mutant p53 function, WO2021061643.

Shipping Conditions

Room Temperature

Storage Conditions

4°C (Powder, protect from light, stored under nitrogen)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Available Sizes

Curated Selection

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