Saikogenin D

Saikogenin D is isolated from Bupleurum chinense, has anti-inflammatory effects. Saikogenin D activates epoxygenases that converts arachidonic acid to epoxyeicosanoids and dihydroxyeicosatrienoic acids, and the metabolites secondarily inhibit prostaglandin E2 (PGE2) production. Saikogenin D results in an elevation of [Ca2+]i due to Ca2+ release from intracellular stores[1][2].

Product Specifications

CAS Number

[5573-16-0]

UNSPSC

12352211

Hazard Statement

H315, H319

Target

Potassium Channel; Prostaglandin Receptor

Type

Natural Products

Related Pathways

GPCR/G Protein; Membrane Transporter/Ion Channel

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/saikogenin-d.html

Purity

99.99

Solubility

DMSO : ≥ 100 mg/mL

Smiles

C[C@]12[C@]3(C(C=C[C@]1([H])[C@@]4([C@@]([C@@](C)([C@@H](O)CC4)CO)([H])CC2)C)=C5[C@](CO)(CCC(C)(C)C5)[C@H](O)C3)C

Molecular Formula

C30H48O4

Molecular Weight

472.70

Precautions

H315, H319

References & Citations

[1]Toriniwa Y, et al. Participation of epoxygenase activation in saikogenin D-induced inhibition of prostaglandin E (2) synthesis.J Pharm Pharmacol. 2006 Jun;58 (6) :859-66.|[2]Kodama Y, et al. Dual effect of saikogenin D: in vitro inhibition of prostaglandin E2 production and elevation of intracellular free Ca2+ concentration in C6 rat glioma cells.Planta Med. 2003 Aug;69 (8) :765-7.